Comparative analysis of the quality of life of women who left the territory of Ukraine during the ongoing Russia - Ukraine war and women who stayed at their homes.

OBJECTIVE: Aim: To investigate the quality of life of women who left Ukraine and those who did not leave their homes under the threat of war. PATIENTS AND METHODS: Materials and Methods: We used the WHOQOL-100 questionnaire for quality assessment. 376 young women (aged 25-44) were interviewed using a Google questionnaire (WHOQOL BREF). The respondents were divided into 2 groups: group 1 - women who left the territory of Ukraine during the war (n-176); group 2 - women who did not leave their homes (n-200). RESULTS: Results: The general level of quality of life for group 1 (62.9% ± 9.3) was slightly lower than group 2 (66.7% ± 9.1). In terms of quality of life, group 2 prevails over group 1 in the domain of microsocial support. CONCLUSION: Conclusions: Therefore, women who did not leave their homes during the full-scale invasion of Russia on the territory of Ukraine rate their quality of life higher than women who left the territory of Ukraine. Respondents of group 2 are more satisfied with their social support, sexual life, support from friends, enjoy life more than respondents of group 1.

REPARATIVE REGENERATION OF PERIAPICAL TISSUES IN CHRONIC GRANULOMATOUS PERIODONTITIS UNDER THE INFLUENCE OF COMPOSITION BASED ON CALCIUM HYDROXYAPATITE.

OBJECTIVE: The aim: To establish the dynamics of reparation processes in periapical tissues in chronic granulomatous periodontitis under the influence of the developed composition based on calcium hydroxyapatite in comparison with the generally accepted drug MTA. PATIENTS AND METHODS: Materials and methods: The main group included 52 individuals, and the comparison group - 19 patients with chronic granulomatous periodontitis. In the first experimental subgroup, patients were obturated of the tooth root apical area with the proposed composition, and in the second experimental subgroup patients were performed obturation of the root canal apical area with additional transcanal withdrawal of the composition into the periapical area. In the comparison group, the tooth root apex was obturated with MTA material. RESULTS: Results: Clinical studies have shown that the composition based on calcium hydroxyapatite, having osteoconductive, antioxidant and anti-inflammatory properties, activates the synthesis of organic and mineral components, that promotes the bioreparation and regeneration processes of periapical tissues in chronic granulomatous periodontitis, which occurred most intensively during the first 6 months after treatment. At the same time, with additional transcanal removal of the filling composition based on calcium hydroxyapatite into the periapical area in patients with chronic granulomatous periodontitis with acquired wide tooth root apex was observed in 1.6 time better results than the method of creating an apical root canal obturation (p <0,05), indicating a high therapeutic effect. CONCLUSION: Conclusions: Composition based on calcium hydroxyapatite, having osteoconductive, antioxidant and anti-inflammatory properties, activates the synthesis of organic and mineral components, which promotes the processes of bioreparation and regeneration of periapical tissues, especially in the early stages. And additional transcanal removal of the filling composition into the periapical space causes the acceleration of the period of periodontal tissues revitalization, bioreparation and regeneration compared to the creation of the apical obturation within the physiological tooth root apex.

PATHOGENETIC MECHANISMS OF COMORBIDITY OF SYSTEMIC DISEASES AND PERIODONTAL PATHOLOGY.

OBJECTIVE: The aim: Of the study is to analyze the literary data regarding evaluation of the pathogenetic mechanisms of the interaction of systemic diseases and periodontal tissue damage, conducted on the basis of scientific researches of Ukrainian and foreign scientists. PATIENTS AND METHODS: Materials and methods: Bibliosematic and analytical methods were used in the research. The materials of the exploration are international experience in the study of pathogenetic mechanisms of the interplay of pathology in the cardiovascular, respiratory systems, diseases of the gastrointestinal tract and chronic generalized damage of periodontal tissues. CONCLUSION: Conclusions: It is important to search for new modern methods of diagnosis and individual approach to primary and secondary prevention of changes in periodontal tissues on the background of general pathology. The only way to solve this problem is a detailed study of somatic and dental history, changes in all body systems, on the basis of which it is possible to create a reasonable set of individual preventive measures and improve the treatment of periodontal disorders.

Periodontal status in patients with diseases of hepatobiliary system, burdened with tobacco and drug addiction.

OBJECTIVE: The aim: To study the effect of drug addiction and smoking on the status of periodontal tissues in patients with hepatobiliary pathology. PATIENTS AND METHODS: Materials and methods: 58 smokers, 63 drug addicts with hepatobiliary pathology were examined and 92 persons of comparison group (with inflammatory periodontal diseases affected by hepatobiliary pathology, without addiction). Examination of patients included determination of iodine number by Svrakov, S-L and Stallard hygiene indices, PMA index and index PBI. RESULTS: Results: The results of examination of smokers are worse in patients with cirrhosis than in patients with chronic toxic hepatitis and non-alcoholic steatohepatitis and also the results of these two groups was significantly worse than that of the comparison group (iodine number by Svrakov - 1,4 times and 1,3 times higher, PMA index - 1,7 times and 1,4 times worse, in accordance). The results of the study showed that drug addicts patients are worse values in patients with cirrhosis than in patients with chronic toxic hepatitis and non-alcoholic steatohepatitis and also the results of these two groups was significantly worse than that of the comparison group (iodine number by Svrakov - 1,5 times and 1,4 times higher, PMA index - 1,7 times and 1,5 times worse, in accordance). CONCLUSION: Conclusions: Presence of hepatobiliary pathology in smokers and drug addicts increases the risk of periodontal diseases.

Chronic heart failure course prognosis depending on body weight and endogenous intoxication syndrome.

OBJECTIVE: Introduction: Over the years, heart failure remains one of the most common and prognostically unfavorable conditions. The aim of our study was to determine the frequency of complications in patients with CHF depending on the body weight and intoxication syndrome of varying degrees of severity. PATIENTS AND METHODS: Materials and methods: A complete clinical examination was performed in 58 patients (41 (70.6%) men and 17 (29.4%) women) with CHF. In addition to the standard examination in accordance with the protocol, the level of endogenous intoxication was determined by the level of medium-weight molecules (MWM254) and leptin. The patients were randomized into 4 groups depending on their body mass index and the degree of endogenous intoxication. Statistical processing of the results was carried out using the methods of variation statistics "Statistica 6.0". RESULTS: Results: It was revealed that the worst survival rate is observed in patients with normal body mass against the background of the expressed endogenous intoxication syndrome, the best survival rate is observed provided that there are a normal body mass and endogenous intoxication of a minimum degree. An inverse correlation between the body mass index and the endogenous intoxication indicator (blood MWM) was detected. Patients with CHF should have their leptin level evaluated. An increase in its level was associated with arterial hypertension, an increase in blood glucose levels and lipid metabolism disorders. CONCLUSION: Conclusions: Increased level of blood MWM worsens the forecast of CHF. The unfavorable outcome was observed in patients with the combination of hypoleptinemia with severe endogenous intoxication.

The role of small intestinal bacterial overgrowth in the pathogenesis of hyperlipidemia.

OBJECTIVE: Introduction: Small intestinal bacterial overgrowth may cause the hyperlipidemia appearance by enterohepatic circulation disturbance which evolves on the background of the early bile acids deconjugation with further endotoxin production and oxidative stress in the liver with hyperproduction of cholesterol and atherogenic lipoproteins. The aim: the determination of prevalence and features of SIBO in a series of patients with hyperlipidemia and in control subjects. PATIENTS AND METHODS: Materials and methods: Nineteen patients with hyperlipidemia and ten control subjects were studied. Small intestinal bacterial overgrowth was assessed by a lactulose breath test. Such biochemical markers as CRP, ALT, AST, GGTP, apolipoprotein B, bilirubin, cholesterol and lipid profile were determined. Except the routine interpretation of lactulose breath test, which contains the SIBO detection, small intestinal transit time and hydrogen level evaluation with next comparison between groups of patients was realized. RESULTS: Results: Small intestinal bacterial overgrowth was present in 78.9% of patients with hyperlipidemia and 40% in control subjects. The maximal dose of H2 was particularly higher in patients with hyperlipidemia in comparison with control group (94,7±13,69 vs. 36,13±5,4). There was a strong correlation between AST level and SIBO existence in both groups (r=1). Positive connection between LDL, TG, VLDL and the dose of exhaled hydrogen on 120 minute (r=0.6, r= 0.62, r=0.7 respectively) and strong negative correlation between HDL and 120 minute dose (r=-0.74) in main group was marked. CONCLUSION: Conclusions: Patients with hyperlipidemia have a higher prevalence of small intestinal bacterial overgrowth and there is a relationship between H2 rate and LDL, TG, VLDL.

ASIT as the component of bronchial asthma's therapy can improve the adherence to the treatment.

OBJECTIVE: The aim: To compare the treatment adherence of patients with Bronchial Asthma (BA) receiving basic treatment and its combination with allergen-specific immunotherapy. PATIENTS AND METHODS: Materials and methods: The study included 104 patients aged from 18 to 50 with BA. All patients were divided into two groups. The main group (MG) consisted of 51 patients receiving basic medical treatment and ASIT. 38 of them received subcutaneous ASIT and 13 patients received sublingual ASIT. The comparative group (CG) consisted of 53 patients who received only basic therapy. The patients' observation duration was for a year. RESULTS: Results: All patients were done the computer spirometry with a bronchodilation test, determination of the total IgE level, questionnaires (quality of life, control of asthma, adherence to treatment). Also the major and minor component of allergy house dust mites and specific IgG4 were determined in patients of main groups. After 12 months of observation in both groups the spirometry rates improved (the main group result was 16.9%, the control group - was 12.8%). The indicators of asthma's control also increased (MG by 28%, in CG - 21%, (p <0,05)). After individual conversations and training the patients improved and adherence to the treatment too. In the beginning of our research the mean level in MG was 3.2 ± 0.3 points, in - CG-3.3 ± 0.2 points (p> 0.05), after 12 months it increased to 6.3 ± 0.2 points in MG vs 5. 8 ± 0.1 points in CG (p <0.05). CONCLUSION: Conclusion: Patients' combining basic therapy with SIT had significantly better results of the overall BA's controllability compared to the patients' receiving only basic therapy.

ASIT therapy: advantages and adverse effects. own results and literature data.

OBJECTIVE: Introduction: Allergy is an important medical, social and economic problem nowadays, as it causes disability and patients' quality of life decreases. According to the update data all the existing therapeutic options haven't been used in huge majority of patients. Allergen-specific immunotherapy (ASIT) underuse in particular. One of the reasons for the low frequency of this treatment method using is the fear of systemic and local allergic. The aim of the study was to find out the incidence and severity of adverse reactions in patients receiving subcutaneous and sublingual ASIT. PATIENTS AND METHODS: Materials and methods: In conducted research we compared peculiarities of adverse reactions using sublingual and subcutaneous ASIT methods. Criteria for inclusion in the research were age from 18 to 50 years, diagnosed intermittent or persistent BA. The investigation involved 51 patients with combined basic drug therapy and ASIT, which was performed with injected allergens for 38 patients and sublingual allergens - for 13 individuals. RESULTS: Results: Local reactions were recorded in five patients (13.16%), who received injected ASIT. In four patients (10.52%), dry rales were observed for a short period after injection of the allergen. Local side effect was observed in one patient (7.69%) during sublingual ASIT. CONCLUSION: Conclusions: Adverse reactions, that occur during ASIT, do not pose a threat to patients' lives. However, the therapeutic effect after the year of treatment was significantly better than in patients who used medications only. Modern drugs are safe and, if all the rules are followed, the risk of adverse effects is very low.